The VISION-CRT trial sponsored by the International Atomic Energy Agency (IAEA), a branch of the United Nations, involves heart failure patients in nine countries: Italy, Algeria, South Africa, Pakistan, India, Colombia, Brazil, Mexico, and Vietnam. SyncTool will be used as part of the nuclear cardiology imaging protocol for the diagnosis of heart failure. This study will include phase analysis for LV Dyssynchrony. 

"Of all heart failure patients, about two-thirds of the patients getting CRT will benefit from that treatment yet one-third will not. Phase analysis of left ventricular dyssynchrony can help with two critical issues: First, how to select the right patient for CRT; and second, where to put the left ventricular lead." 

SyncTool used in IAEA sponsored clinical trial to help improve heart failure diagnosis in at-risk groups.

Emory University nuclear cardiology researchers have been at the forefront of research evaluating SPECT MPI versus Speckle Tracking Echocardiology (STE) for the diagnosis of heart failure. Studies show that patients respond more favorably if the left ventricular lead is positioned in the right place. The technology for SyncTool is based on multi-harmonic phase analysis research originally developed by E.V. Garcia and J. Chen at Emory University. 

SPECT MPI versus Speckle Tracking Echocardiology (STE).

--Ji Chen, PhD, Associate Professor of Radiology and Nuclear Cardiology R&D at Emory University

Emory Toolbox is the only imaging software system on the market for evaluating two different avenues of heart failure and quantitatively providing a more accurate diagnosis of the disease.





 




 



       





 

SyncTool is a phase analysis software tool that analyzes the benefits of cardiac resynchronization therapy (CRT) in heart failure patients. It has been proven to be more sensitive than TDI Echo to analyze LV Dyssynchrony. SyncTool analysis takes just seconds and uses the same data from perfusion studies. The reporting process can also be applied to any Gated SPECT MPI data set or previously stored image, and provides prognostic information from the 3D perfusion images about the presence and location of scar tissue. In addition to myocardial perfusion SPECT and PET studies, SyncTool can also be used with FDG-PET studies for patients with ischemic cardiomyopathy.

1/3 of patients do not benefit from CRT. SyncTool improves the ability to
pinpoint where to put the left ventricular lead.

SyncTool for better heart failure patient selection.

This screen displays the results of phase analysis of the gated stress and rest studies. For each study the following items are shown: 

A phase polar map

A histogram plotting the frequency of occurrence of each possible phase (0-360) within the polar map

The raw polar map shown twice. The rightmost one will contain an animation of the wave of contraction when the Animation control's Play button is left-clicked.


A list of calculated values that characterize the phase histogram

LV Dyssynchrony Analysis

SyncTool is proven to be more sensitive than TDI Echo to analyze LV Dyssynchrony and the benefits of cardiac resynchronization therapy (CRT)

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SyncTool

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