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Nuclear Cardiology

Training

In this PowerPoint slideshow, Dr. Garcia shows case based interpretation of more difficult cases.

SPECT

Amalia Peix, Claudio Tinoco Mesquita, Diana Paez, Carlos Cunha Pereira, Renata Felix, Claudia Gutierrez, Rodrigo Jaimovich, Barbara Maria Ianni, Jose Soares Jr, Pastor Olayah, M. Victoria Rodriguez, Albert Flotats, Raffaele Giubbini, Mark Travin and Ernest V. Garcia: "Nuclear medicine in the management of patients with heart failure: guidance from an expert panel of the International Atomic Energy Agency (IAEA)". Nucl Med Commun 35:818–823, 2014

Cooke CD, Esteves FP, Chen J, Garcia EV: "Left ventricular mechanical synchrony from stress and rest 82Rb PET myocardial perfusion ECG-gated studies: Differentiating normal from LBBB patients." J Nucl Cardiol 18(6):1076-1085, 2011.

Chen J, Garcia EV, Bax JJ, Iskandrian AE, Borges-Neto S, Soman P: "SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony". J Nucl Cardiol 18(4):685-694, 2011.

Samad Z, Atchley AE, Trimble MA, Sun JL, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S: Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging. J Nucl Cardiol 18(1):23-30, 2011.

Boogers MJ, Chen J, van Bommel RJ, Borleffs CJ, Dibbets-Schneider P, van der Heil B, AI Younis I, Schalij MJ, van der Wall EE, Garcia EV, Bax JJ: Optimal left ventricular lead position assessed with phase analysis on gated myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging 38:230-8, 2011.

Lin X, Xu H, Zhao X, Folks RD, Faber TL, Garcia EV, Chen J: Repeatability of left ventricular dyssynchrony and function parameters in serial gated myocardial perfusion SPECT studies. J Nucl Cardiol 17:811-6, 2010.

Atchley AE, Trimble MA, Samad Z, Shaw LK, Pagnanelli R, Chen J, Garcia EV, Iskandrian AE, Velazquez EJ, Borges-Neto S: "Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction". J Nucl Cardiol 16:888-94, 2009.

Chen J, Faber TL, Cooke CD, Garcia EV. "Temporal resolution of multiharmonic phase analysis of ECG-gated myocardial perfusion SPECT studies". JNC 15(3):383-391, 2008.

Nichols KJ, Van Tosh A, Wang Y, Chen J, Garcia EV, Palestro CJ, Reichek N: "Relationship between blood pool and myocardial perfusion gated SPECT global and regional LV function measurements". Nucl Med Commun 30:292-9, 2009.
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Brandao SCS, Nishioka SAD, Giorgi MCP, Chen J, Abe R, Filho MM, Hotta VT, Vieira ML, Garcia EV, Meneghetti JC: "Cardiac resynchronization therapy evaluated by myocardial scintigraphy with Tc-99m-MIBI: Changes on left ventricular uptake, dyssynchrony, and function". Eur J Nucl Med Mol Imaging 36:986-96, 2009.

Nichols KJ, Van Tosh A, Siddiqi S, Chen J, Garcia EV, Palestro CJ, Reichek N: "Gated myocardial perfusion SPECT asynchrony measurements in patients with left bundle branch block". Int J Cardiovasc Imaging 25:43-51, 2009.

Li D, Zhou Y, Feng J, Yuan D, Cao K, Garcia EV, Chen J: Impact of image reconstruction on phase analysis of ECG-gated myocardial perfusion SPECT studies. Nuc Med Commun 30:700-5, 2009.

Mark A. Trimble, MD, Salvador Borges-Neto, MD, Emily F. Honeycutt, MS, Linda K. Shaw, MHS, Robert Pagnanelli, CNMT, NCT, Ji Chen, PhD, Ami E. Iskandrian, MD, Ernest V. Garcia, PhD, Eric J. Velazquez, MD. "Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction". JNC 15(5):663-670, 2008.

Marsan NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ. "Real-time three-dimensional echocardiography as a novel approach to quantify left ventricular dyssynchrony: a comparison study with phase analysis of gated myocardial perfusion single photon emission computed tomography". J Am Soc Echo 21(7):801-807, 2008.

Trimble MA, Borges-Neto S, Velazquez EJ. Chen J. Shaw LK. Pagnanelli R. Garcia EV. Iskandrian AE. "Emerging role of myocardial perfusion imaging to evaluate patients for cardiac resynchronization therapy". AJC 102(2):211-217, 2008.

Trimble MA, Velazquez EJ, Adams GL, Honeycutt EF, Pagnanelli RA, Barnhart HX, Chen J, Iskandrian AE, Garcia EV, Borges-Neto S. "Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony". Nuc Med Comm 29(4):374-381, 2008.

Chen J, Garcia EV, Henneman MM, Bax JJ, Boogers MJ, Trimble MA, Borges-Neto S, Velazquez EJ, Iskandrian AE. "Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging". Minerva Cardioangiologica. 56(2):227-235, 2008.

Chen J, Henneman MM, Trimble MA, Bax JJ, Borges-Neto S, Iskandrian AE, Nichols KJ, Garcia EV. "Assessment of left ventricular mechanical dyssynchrony by phase analysis of ECG-gated SPECT myocardial perfusion imaging". JNC 15(1):127-136, 2008.
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Marson NA, Henneman MM, Chen J, Ypenburg C, Dibbets P, Ghio S, Bleeker GB, Stokkel MP, van der Wall EE, Tavazzi L, Garcia EV, Bax JJ. "Left ventricular dyssynchrony assessed by two 3-dimensional imaging modalities: phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging." Eur J Nucl Med Mol Imag 35(1):166-173, 2008.


Phase Analysis/ (SyncTool™)

Santana CA, Folks RD, Rivero A, Grossman GB, Cooke CD, Faber TL, Hunsche A, Halkar R, Garcia EV: "Comparison of the Extent of the Myocardial Perfusion Defect Using Three Different Totally Automatic Programs for the Quantification of Myocardial Perfusion SPECT". J Nucl Med 45(5):221P, 2004.

Santana CA, Rivero A, Folks RD, Grossman GB, Cooke CD, Hunsche A, Faber TL, Halkar R, Garcia EV: "Diagnostic Performance of Totally Automatic vs. Manual Processing for the Quantification of Myocardial Perfusion SPECT". J Nucl Cardiol 11(4):S4, 2004.

Ernest V. Garcia, C. David Cooke, Russell D. Folks, Cesar A. Santana, Elzbieta G. Krawczynska, Levien De Braal and Norberto F. Ezquerra: "Diagnostic Performance of an Expert System for the Interpretation of Myocardial Perfusion SPECT Studies". J Nucl Med 42(8): 1185-1191, 2001.

Perfex

Compare Emory Toolbox,
QPS and 4DMSPECT

Nichols K, Yao SS, Kamran M, Faber TL, Cooke CD, DePuey EG. "Clinical impact of arrhythmias on gated SPECT cardiac myocardial perfusion and function assessment". J Nuclear Cardiology, 8(1):19-30, January/February, 2001.

Akincioglu C, Berman D, Nishina H, Kavanagh P, Slomka P, Abidov A, Hayes S, Friedman J, Germano G. "Assessment of Diastolic Function Using 16-Frame Tc-Sestamibi Gated Myocardial Perfusion SPECT: Normal Values". J Nuclear Medicine, 46 (7): 1102-1108, July 2005.

Gated Quality Control

Ballal S, Patel CD, Singla S, Sharma P, Narang R, Sharma G, Malhotra A: "Comparison of software programs for the assessment of left ventricular ejection fraction using 99mTc-tetrofosmin-gated SPECT/CT: correlation with equilibrium radionuclide ventriculography in the Indian population". Nucl Med Commun 33(11):1160-8, 2012.

Harisankar CN, Mittal BR, Kamaleshwaran KK, Parmar M, Bhattacharya A, Singh B, Mahajan R: Reliability of left ventricular ejection fraction calculated with gated myocardial perfusion single photon emission computed tomography in patients with extensive perfusion defect. Nucl Med Commun 32(6):503-7, 2011.

Dostbil Z, Arıtürk Z, Cil H, Elbey MA, Tekbaş E, Yazıcı M, Yıldız I, Taşdemir B: "Comparison of left ventricular functional parameters obtained from three different commercial automated software cardiac quantification program packages and their intraobserver reproducibility". Ann Nucl Med 25(2):125-31, 2011.

Khalil MM, Elgazzar A, Khalil W. "Evaluation of left ventricular ejection fraction by the quantitative algorithms QGS, ECTb, LMC and LVGTF using gated myocardial perfusion SPECT: investigation of relative accuracy". Nuclear Medicine Communications, 27(4):321-332, April, 2006.

Khalil MM, Elgazzar A, Khalil W, Omar A, Ziada G. "Assessment of left ventricular ejection fraction by four different methods using 99mTc tetrofosmin gated SPECT in patients with small hearts: correlation with gated blood pool". Nuclear Medicine Communications, 26(10):885-893, October, 2005.

Schaefer WM, Lipke CS, Standke D, Kuhl HP, Nowak B, Kaiser HJ, Koch KC, Buell U. "Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation and comparison of the Emory Cardiac Tool Box with QGS and 4D-MSPECT". J Nuclear Medicine, 46(8):1256-1263, August, 2005.

Lum DP and Coel MN. "Comparison of automatic quantification software for the measurement of ventricular volume and ejection fraction in gated myocardial perfusion SPECT". Nuclear Medicine Communications, 24(3):259-266, March, 2003.

Nichols K, Santana CA, Folks R, et al. "Comparison between ECTb and QGS for assessment of left ventricular function from gated myocardial perfusion SPECT". J Nuclear Cardiology, 9(3):285-293, May/June 2002.

Nakajima K, Higuchi T, Taki J, Kawano M, Tonami N. "Accuracy of Ventricular Volume and Ejection Fraction Measured by GatedMyocardial SPECT: Comparison of 4 Software Programs". JNucl Med. 2001: 42:1571-1578.

Faber TL, Vansant JP, Pettigrew RI, et al. Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with MR: Comparison of two methods. J Nuclear Cardiology, 8(6):645-651, November/December, 2001.

Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su HT, Van Train KF, Berman DS. "Automatic quantification of ejection fraction from gated myocardial perfusion SPECT". J Nucl Med 36(11):2138-2147, 1995.


Comparison of Ejection Fraction Methods

Garcia EV. Faber TL. Cooke CD. Folks RD. Chen J. Santana C.: "The increasing role of quantification in clinical nuclear cardiology: The Emory approach". Journal of Nuclear Cardiology. 2007: 14 (4); 420-32.

PET/SPECT

Emory Toolbox

Strain

MBF (FlowTool™)

Heart Failure

Publications

(Book)

CN De Cecco, M van Assen, T Leiner - 2022: Artificial Intelligence in Cardiothoracic Imaging. This book provides an overview of current and potential applications of artificial intelligence (AI) for cardiothoracic imaging. Most AI systems used in medical imaging are data-driven …books.google.com
Related articles, All 3 versions 

A Haffar, P Raggi, J Goldberg, NL Smith, EV Garcia, et al. "Posttraumatic stress disorder, myocardial perfusion, and myocardial blood flow: A longitudinal twin study." Biological Psychology, Volume 91, Issue 7, 1 April 2022, Pages 615-625
Cited by 9, Related articles, All 5 versions

MH Hall, RP Sloan, J Goldberg, NL Smith, EV Garcia. "Obstructive sleep apnea, myocardial perfusion and myocardial blood flow: A study of older male twins." PLoS One. 2022; 17(11): e0278420. Published online 2022 Nov 30. doi: 10.1371/journal.pone.0278420
Related articles, All 7 versions 

CD Cooke, KF Van Train, EV Garcia, et al. "18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease …" European Heart Journal - Cardiovascular Imaging, Volume 23, Issue 12, December 2022, Pages 1636–1644,
[HTML] lww.com
Cited by 3, Related articles, All 5 versions

JM Lee, HS Bom, BK Koo, A Yezzi, EV Garcia, et al. "Clinically viable myocardial CCTA segmentation for measuring vessel-specific myocardial blood flow from dynamic PET/CCTA hybrid fusion." European J Hybrid Imaging, 6, 4 (2022). https://doi.org/10.1186/s41824-021-00122-1
[HTML] springer.com, Related articles, All 10 versions

R Folks, M Haber, HS Bom, BK Koo, EV Garcia, et al. "Determination of [N-13]-ammonia extraction fraction in patients with coronary artery disease by calibration to invasive coronary and fractional flow reserve." Journal of Nuclear Cardiology, 29, 2210–2219 (2022). https://doi.org/10.1007/s12350-021-02628-4
Related articles, All 6 versions




(Strain) 
J Huang, AJ Mitchell, EV Garcia. "Left Ventricular Strain from Myocardial Perfusion Positron Emission Tomography imaging: Method Development and Comparison to 2-Dimensional Echocardiography." Journal of Nuclear Medicine, Society of Nuclear Medicine, Dec. 2022, jnumed.122.264516. 64(6):932-939. DOI: https://doi.org/10.2967/jnumed.122.264516
Related articles, All 4 versions

J Huang, AJ Mitchell, EV Garcia, CD Cooke, et al. "Correlation of Left Ventricular Strain Derived From Rb-82 ECG-Gated PET Myocardial Perfusion Imaging vs 2D Echocardiography." Journal of Nuclear Medicine, Dec. 2022, jnumed.122.264516;
DOI: https://doi.org/10.2967/jnumed.122.264516. 
Related articles

(Journals)

Z Almuwaqqat, EV Garcia, CD Cooke, M Garcia, et al. "Quantitation of diffuse myocardial ischemia with mental stress and its association with cardiovascular events in individuals with recent myocardial infarction"
Journal of Nuclear Cardiology, (2023). https://doi.org/10.1007/s12350-023-03212-8 
All 2 versions

L Ward, M Kutner, Y Hu, TT Lewis, EV Garcia, et al. "Mental Stress-Induced Hemodynamic Changes and Cardiovascular Outcomes." American Heart Assoc. Circulation, 2022. 146:A13149
Related articles

EV Garcia, M Piccinelli. "Preparing for the Artificial Intelligence Revolution in Nuclear Cardiology." Nuclear Medicine and Molecular Imaging, 57, 51–60 (2023). https://doi.org/10.1007/s13139-021-00733-3
Related articles
[PDF] arxiv.org

EV Garcia. Integrating artificial intelligence and natural language processing for computer-assisted reporting and report understanding in nuclear cardiology. Journal of Nuclear Cardiology, June, 2022. https://doi.org/10.1007/s12350-022-02996-5
Related articles, All 3 versions

M Piccinelli, C Cooke, R Folks, E Garcia. "4D dynamic display of CT left ventricular endocardial and epicardial surface models morphed from PET Rb-82 perfusion studies accurately assesses segmental …". Journal of Nuclear Medicine, June 2022, 63 (supplement 2) 3382
Related articles

M Piccinelli, EV Garcia. Cardiac Nuclear Medicine: The Role of Artificial Intelligence. In: De Cecco, C.N., van Assen, M., Leiner, T. (eds), Artificial Intelligence in Cardiothoracic Imaging. Contemporary Medical Imaging. Humana, Cham. 2022. https://doi.org/10.1007/978-3-030-92087-6_37
Related articles, All 2 versions

A Comelli, A Stefano, M Piccinelli, E Garcia. "Combining Convolutional Neural Networks and Anatomical Shape-Based Priors for Cardiac Segmentation.” In: Mazzeo, P.L., Frontoni, E., Sclaroff, S., Distante, C. (eds) Image Analysis and Processing. ICIAP 2022 Workshops. ICIAP 2022. Lecture Notes in Computer Science, vol 13373. Springer, Cham. https://doi.org/10.1007/978-3-031-13321-3_37
Related articles, All 2 versions

EV Garcia, JA Nye. “Moving forward with motion reduction, detection and correction in cardiac PET.” Journal of Nuclear Cardiology, 29, 1607–1610 (2022). https://doi.org/10.1007/s12350-021-02599-6
[HTML] springer.com
Cited by 2, Related articles, All 3 versions



O Morozova, D Paez, CT Mesquita, EV Garcia. "Reproducibility of global LV function and dyssynchrony parameters derived from phase analysis of gated myocardial perfusion SPECT: A multicenter comparison with …". Journal of Nuclear Cardiology, 29, 952–961 (2022). https://doi.org/10.1007/s12350-020-02397-6. [PDF] uchile.cl, Cited by 7, Related articles, All 7 versions

V Marin, O Morozova, D Paez, EV Garcia, et al. "Clinical and gated SPECT MPI parameters associated with super-response to cardiac resynchronization therapy." Journal of Nuclear Cardiology. 29, 1166–1174 (2022). https://doi.org/10.1007/s12350-020-02414-8
Cited by 8, Related articles, All 6 versions

A Peix, Q Sha, D Paez, EV Garcia, et al. "A new method using machine learning to integrate ECG and gated SPECT MPI for Cardiac Resynchronization Therapy Decision Support on behalf of the VISION-CRT." https://doi.org/10.48550/arXiv.2211.07472
Related articles, All 2 versions

R Mullick, N Ezquerra, E Garcia, C Cooke, R Folks. "3-dimensional visualization of pose determination: application to SPECT imaging (Proceedings Only), spiedigitallibrary.org
Related articles

Dahiya, N., Piccinelli, M., Garcia, E., Yezzi, A. “Shape Prior Based Myocardial Segmentation with Anatomically Motivated Pose Model.” In: Mazzeo, P.L., Frontoni, E., Sclaroff, S., Distante, C. (eds) Image Analysis and Processing. ICIAP 2022 Workshops. ICIAP 2022. Lecture Notes in Computer Science, vol 13373. Springer, Cham. https://doi.org/10.1007/978-3-031-13321-3_30
Related articles, All 2 versions

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